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Chiefs vs 49ers

Kansas City Chiefs vs San Francisco 49ers: Odds and Predictions

Kansas City Chiefs and San Francisco 49ers sit in opposite conferences, so a regular-season meeting comes around rarely. This page tracks the Kalshi markets for the matchup — moneyline, spread and total — alongside the meetings already played and the ones still to come.No Chiefs vs 49ers game is currently listed on Kalshi.

vs

Head-to-head

Every Chiefs vs 49ers meeting on the schedule

The games these two clubs play against each other — still to come first, then already played — with the Kalshi market for any that is listed.

Sun, Dec 27 · 4:25 PM ET

San Francisco 49ers

Kansas City Chiefs

NFL · Week 16

Upcoming

Next games for the Chiefs and 49ers

Every fixture either club plays next, whoever the opponent is, with the Kalshi market where one is listed.

Sun, Oct 11 · 4:25 PM ET

San Francisco 49ers

Seattle Seahawks

Sun, Oct 18 · 4:25 PM ET

Los Angeles Chargers

Kansas City Chiefs

NFL · Week 6

Mon, Oct 19 · 8:15 PM ET

Washington Commanders

San Francisco 49ers

NFL · Week 6

Sun, Oct 25 · 1:00 PM ET

San Francisco 49ers

Atlanta Falcons

NFL · Week 7

Sun, Oct 25 · 8:20 PM ET

Kansas City Chiefs

Seattle Seahawks

NFL · Week 7

Sun, Nov 1 · 4:25 PM ET

Kansas City Chiefs

Denver Broncos

NFL · Week 8

Sun, Nov 8 · 1:00 PM ET

New York Jets

Kansas City Chiefs

NFL · Week 9

Sun, Nov 8 · 4:05 PM ET

Las Vegas Raiders

San Francisco 49ers

NFL · Week 9

Sun, Nov 15 · 1:00 PM ET

Kansas City Chiefs

Atlanta Falcons

NFL · Week 10

Sun, Nov 15 · 4:25 PM ET

San Francisco 49ers

Dallas Cowboys

NFL · Week 10

Recent form

Recent games for the Chiefs and 49ers

The last games each club played, whoever the opponent was — with the final score where one is available, and the market page for any that Kalshi listed.

Sun, Oct 4 · 4:25 PM ET

Kansas City Chiefs

Las Vegas Raiders

Sun, Oct 4 · 4:25 PM ET

San Francisco 49ers

Sun, Sep 27 · 4:05 PM ET

Arizona Cardinals

San Francisco 49ers

Sun, Sep 27 · 1:00 PM ET

Kansas City Chiefs

Sun, Sep 20 · 8:20 PM ET

Indianapolis Colts

Kansas City Chiefs

Around the league

Other games this week

The rest of that week's league slate, without these two clubs, so the next thing to trade is one click away.

Sun, Oct 11 · 4:05 PM ET

Los Angeles Chargers

Sun, Oct 11 · 1:00 PM ET

Las Vegas Raiders

New England Patriots

Sun, Oct 11 · 4:25 PM ET

Arizona Cardinals

Mon, Oct 12 · 8:15 PM ET

Los Angeles Rams

Thu, Oct 8 · 8:15 PM ET

Tampa Bay Buccaneers

Sun, Oct 11 · 9:30 AM ET

Philadelphia Eagles

Jacksonville Jaguars

Sun, Oct 11 · 1:00 PM ET

Cincinnati Bengals

Sun, Oct 11 · 1:00 PM ET

Cleveland Browns

FAQ

Chiefs vs 49ers questions

When do the Chiefs and 49ers play next?

The Kansas City Chiefs and the San Francisco 49ers meet once in the 2026 regular season: Week 16 in Kansas City. Kickoff times come from the NFL’s published schedule and are shown in Eastern time. A game the league flexes keeps its week while its day and time move, so it shows a date without a time until the slot is fixed.

Are the Chiefs and 49ers in the same division?

No, and not the same conference either. The Kansas City Chiefs play in the AFC West and the San Francisco 49ers in the NFC West — one an AFC club, the other NFC. That makes any meeting between them an interconference game, which the league schedules on a rotation rather than every season.

What is at stake when the Chiefs play the 49ers?

For the Chiefs and the 49ers, the overall record and only that. An interconference game touches neither club’s division record nor its conference record — but the overall record is where every seeding decision starts, and it feeds the strength-of-victory measures the league falls back on when nothing closer separates two clubs.

Can the Chiefs and 49ers meet in the playoffs?

Only in the Super Bowl. The Chiefs are in the AFC and the 49ers in the NFC, and the playoffs are run inside each conference until the final — so these two cannot be drawn against each other before it.

How often do the Chiefs and 49ers play each other?

Rarely. AFC and NFC divisions are matched in full once every four seasons, so the AFC West and the NFC West meet on that rotation. Outside it, the single interconference game each club plays against a same-position finisher can bring the Chiefs and the 49ers together sooner.

Where can I follow the Chiefs and 49ers for the rest of the season?

Each club has its own page on Kalshi. The Kansas City Chiefs and San Francisco 49ers hubs carry the roster, the weekly injury report, the remaining schedule, the division standings and the market’s read on each club’s division, playoff and Super Bowl chances.

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